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"Bits" and Pieces

Many protein-protein interactions involved in signal transduction occur through the interaction of modular protein domains in one molecule with short linear sequences of amino acids ("motifs") in another. Although protein domains are recognized by a variety of computational tools, bioinformatic approaches alone have not been successful in identifying the short sequence motifs to which domains bind. A new approach, applying motif-determining algorithms to smaller subproteomic collections of proteins that are already known to associate with each other in high-throughput protein-protein interaction screens, now appears to be capable of capturing a reasonably large number of low-affinity core motif sequences. Application of this approach to the genomes of yeast, fruit flies, nematodes, and humans has doubled the number of known or suspected protein-protein interaction motifs.

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User Rating: 3.7 / 5 stars - 36 vote(s).


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Resource Type: Bibliography, Diagram, Illustration, Journal article/Issue, Table
Discipline: Biochemistry, Bioinformatics Genomics & Proteomics, Cell biology, Molecular Biology, Structural biology
Pedagogical Use: Learn, Research, Teach
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: Michael B. Yaffe of Center for Cancer Research, MA
Publisher: American Association for the Advancement of Science
Date Published: 2006-06-20
Date Added to BEN: 2011-06-01
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes
Cost Description: Copyright © 2006 by the American Association for the Advancement of Science and the Board of Trustees of the Leland Stanford Junior University

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Collection:
STKE/Science Signaling



"Complementing" Toll Signaling

Studies of signal transduction are often focused on dissecting the cellular response to a single stimulus that activates a single receptor. These types of studies laid the foundation for our current understanding of signaling, as well as the generation of countless arrow-containing models in today’s textbooks. Implicit in most models is the suggestion that the arrows emanating from an activated receptor represent the core signaling pathways that are always activated by a given receptor, thus leading to a core cellular response. In nature, however, it is likely that no signaling pathway is activated in isolation. Rather, cells often respond to multiple stimuli simultaneously, and the cellular response may be the result of several signaling pathways. A new study attempts to model such conditions in vitro and reveals that when macrophages encounter bacteria, two signal transduction pathways interact in a way that profoundly alters the cellular response to infection.

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User Rating: 3 / 5 stars - 5 vote(s).


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Resource Type: Bibliography, Diagram, Illustration, Journal article/Issue, Review
Discipline: Cell biology, Human Biology, Immunology, Microbiology
Pedagogical Use: Learn, Research, Teach
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: Jonathan C. Kagan of Division of Gastroenterology and Harvard Medical School, Children's Hospital Boston
Publisher: American Association for the Advancement of Science
Date Published: 2010-05-04
Date Added to BEN: 2013-05-11
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes
Cost Description: Copyright © 2010 by the American Association for the Advancement of Science and the Board of Trustees of the Leland Stanford Junior University

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Collection:
STKE/Science Signaling



"Feebleminded" girl
Site: DNA Interactive (www.dnai.org)


DNAi location:
Chronicle>Threat of the Unfit>threats
"Feebleminded" girl, undated. Reverse side reads: A good looking girl. Tests about 8 mentally. Was picked up for prostitution. Loves her home and would not attempt to escape."

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User Rating: 3.3 / 5 stars - 18 vote(s).


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Classifications


Resource Type: image
Discipline: genetics & health, neurobiology, population biology, psychology, reproductive biology, sociobiology, public health
Audience Level: General public & informal education

Author and Copyright


Authors and Editors: David Micklos of DNA Learning Center, Cold Spring Harbor Laboratory, Jan Witkowski of Banbury Center, Cold Spring Harbor Laboratory, Garland Allen of Biology Department, Washington University at St. Louis, Elof Carlson of Biology Department, SUNY at Stony Brook, Paul Lombardo of Center for Biomedical Ethics, University of Virginia, Steven Selden of Education Policy and Leadership Department, University of Maryland
Publisher: Cold Spring Harbor Laboratory
Date Published: 2008-10-06
Date Added to BEN: 2008-10-17
Format: application/x-shockwave-flash
Copyright and other restrictions: Yes
Cost: No
Cost Description: Copyright © 1999-2008: Cold Spring Harbor Laboratory; All rights reserved.

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Collection:
Dolan DNA Learning Center



"Feebleminded" people, still image
Site: DNA Interactive (www.dnai.org)


DNAi location:
Chronicle>Threat of the Unfit>threats
This slide was used by Harry Laughlin to illustrate feeblemindeness. Eugenicists reacted to the problem of mental illness and sought to lessen the threat of the "unfit" to the United States.

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User Rating: 3.2 / 5 stars - 17 vote(s).


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Classifications


Resource Type: image
Discipline: genetics & health, neurobiology, population biology, psychology, reproductive biology, sociobiology, public health
Audience Level: General public & informal education

Author and Copyright


Authors and Editors: David Micklos of DNA Learning Center, Cold Spring Harbor Laboratory, Jan Witkowski of Banbury Center, Cold Spring Harbor Laboratory, Garland Allen of Biology Department, Washington University at St. Louis, Elof Carlson of Biology Department, SUNY at Stony Brook, Paul Lombardo of Center for Biomedical Ethics, University of Virginia, Steven Selden of Education Policy and Leadership Department, University of Maryland
Publisher: Cold Spring Harbor Laboratory
Date Published: 2008-10-06
Date Added to BEN: 2008-10-17
Format: application/x-shockwave-flash
Copyright and other restrictions: Yes
Cost: No
Cost Description: Copyright © 1999-2008: Cold Spring Harbor Laboratory; All rights reserved.

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Collection:
Dolan DNA Learning Center



"Fossil Virus" (The Human Body-Kinetic City)

The Fossil Virus (Omega Pack) is a learning module centered on the adaptation and evolution; it is a part of the Kinetic City-Mission to Vearth site (see description below). In general this module is concerned with how changes in the environment can affect the animals that live there. This learning object may be used as reinforcement of learning objectives accomplished in the classroom. The Fossil Virus module is equipped with a computer simulation mind game, creative writing exercises for independent study, and art-centered exercises, as well as lesson plans for hands on games and activities designed for a group. The focus of the activities is evolution and the features of an animal that helps the animal survive in its environment. Certain features explored are the giraffes neck, polar bears fir, and a birds beak. KINETIC CITY DESCRIPTION: "Kinetic City" (www.kineticcity.com) is a fun, Web-based after-school science club for kids, ages 8 through 11. It combines exciting online animations and activities with boxes of hands-on science experiments. Children earn "Kinetic City" power points and collect stickers as they complete missions and learn standards-based science content. Here's how it works: The "Kinetic City" super crew (Keisha, Curtis, Megan and Max) needs the help of Earth kids to save their planet Vearth, from the science-distorting computer virus Deep Delete. Each of Deep Delete's 60 hideous strains attacks a different area of science with disastrous consequences. After each attack, teams of Earth kids fight back by viewing a short online animation describing the situation on Vearth; performing a series of activities to re-learn the lost science and going on a mission to Vearth during which they answer science questions and gobble up Deep Delete viruses. Their scores appear on their own Kinetic City Club Web page. "Kinetic City" is produced by the American Association for the Advancement of Science (AAAS), with a grant from the National Science Foundation. AAAS writes the "Project 2061 Benchmarks for Science Literacy," which forms the basis of most state science standards.

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User Rating: 3.2 / 5 stars - 19 vote(s).


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Classifications


Resource Type: Animation, Simulation, Assignment/Activity (non-laboratory)
Discipline: Evolutionary Biology, Paleontology
Pedagogical Use: Learn, Teach
Audience Level: Middle school 6-8, High school lower division 9-10, High school upper division 11-12

Author and Copyright


Authors and Editors: American Association for the Advancement of Science
Publisher: AAAS
Date Published: 2005-01-01
Date Added to BEN: 2008-05-15
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
American Association for the Advancement of Science



"Grinder Virus" (Diversity of Life - Kinetic City)

The Grinder Virus (Omega Pack) is a learning module centered on the diversity of life; it is a part of the Kinetic City-Mission to Vearth site (see description below). This learning object may be used as reinforcement of learning objectives accomplished in the classroom. The Grinder Virus module is equipped with a computer-based simulation mind game, creative writing assignments for independent study, and art-centered exercises, as well as lesson plans for hands on games and activities. A major focus is on the classification of the diverse life forms. Target life forms are dogs, fish, trees, birds, worms, water lilies, including any plants and animals as well as the environments they live in. KINETIC CITY DESCRIPTION: "Kinetic City" (www.kineticcity.com) is a fun, Web-based after-school science club for kids, ages 8 through 11. It combines exciting online animations and activities with boxes of hands-on science experiments. Children earn "Kinetic City" power points and collect stickers as they complete missions and learn standards-based science content. Here's how it works: The "Kinetic City" super crew (Keisha, Curtis, Megan and Max) needs the help of Earth kids to save their planet Vearth, from the science-distorting computer virus Deep Delete. Each of Deep Delete's 60 hideous strains attacks a different area of science with disastrous consequences. After each attack, teams of Earth kids fight back by viewing a short online animation describing the situation on Vearth; performing a series of activities to re-learn the lost science and going on a mission to Vearth during which they answer science questions and gobble up Deep Delete viruses. Their scores appear on their own Kinetic City Club Web page. "Kinetic City" is produced by the American Association for the Advancement of Science (AAAS), with a grant from the National Science Foundation. AAAS writes the "Project 2061 Benchmarks for Science Literacy," which forms the basis of most state science standards.

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User Rating: 3.1 / 5 stars - 16 vote(s).


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Resource Type: Animation, Audio, Simulation, Assignment/Activity (non-laboratory)
Discipline: Botany & Plant Science, Zoology
Pedagogical Use: Learn, Teach
Audience Level: Middle school 6-8, High school lower division 9-10, High school upper division 11-12

Author and Copyright


Authors and Editors: American Association for the Advancement of Science
Publisher: AAAS
Date Published: 2005-01-01
Date Added to BEN: 2008-05-15
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
American Association for the Advancement of Science



"Mental disorders in twins", still image
Site: DNA Interactive (www.dnai.org)


This display was presented at the Third International Eugenics Conference in 1932.

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User Rating: 3 / 5 stars - 15 vote(s).


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Classifications


Resource Type: image
Discipline: genetics & health, neurobiology, population biology, psychology, reproductive biology, sociobiology, public health
Audience Level: General public & informal education

Author and Copyright


Authors and Editors: David Micklos of DNA Learning Center, Cold Spring Harbor Laboratory, Jan Witkowski of Banbury Center, Cold Spring Harbor Laboratory, Garland Allen of Biology Department, Washington University at St. Louis, Elof Carlson of Biology Department, SUNY at Stony Brook, Paul Lombardo of Center for Biomedical Ethics, University of Virginia, Steven Selden of Education Policy and Leadership Department, University of Maryland
Publisher: Cold Spring Harbor Laboratory
Date Published: 2008-10-06
Date Added to BEN: 2008-10-17
Format: application/x-shockwave-flash
Copyright and other restrictions: Yes
Cost: No
Cost Description: Copyright © 1999-2008: Cold Spring Harbor Laboratory; All rights reserved.

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Collection:
Dolan DNA Learning Center



"Nastro Virus" (The Human Body - Kinetic City)

The Nastro Virus (Omega Pack) is a learning module centered on the human body and its bodily functions; it is a part of the Kinetic City-Mission to Vearth site (see description below). Targeted body parts are the lungs, stomach, muscles, and bones. This module includes a computer-simulated mind game, creative writing assignments for independent study, and art-centered exercises, as well as lesson plans for hands on games and activities designed for a group. KINETIC CITY DESCRIPTION: "Kinetic City" (www.kineticcity.com) is a fun, Web-based after-school science club for kids, ages 8 through 11. It combines exciting online animations and activities with boxes of hands-on science experiments. Children earn "Kinetic City" power points and collect stickers as they complete missions and learn standards-based science content. Here's how it works: The "Kinetic City" super crew (Keisha, Curtis, Megan and Max) needs the help of Earth kids to save their planet Vearth, from the science-distorting computer virus Deep Delete. Each of Deep Delete's 60 hideous strains attacks a different area of science with disastrous consequences. After each attack, teams of Earth kids fight back by viewing a short online animation describing the situation on Vearth; performing a series of activities to re-learn the lost science and going on a mission to Vearth during which they answer science questions and gobble up Deep Delete viruses. Their scores appear on their own Kinetic City Club Web page. "Kinetic City" is produced by the American Association for the Advancement of Science (AAAS), with a grant from the National Science Foundation. AAAS writes the "Project 2061 Benchmarks for Science Literacy," which forms the basis of most state science standards.

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User Rating: 2.9 / 5 stars - 16 vote(s).


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Classifications


Resource Type: Animation, Audio, Simulation, Assignment/Activity (non-laboratory)
Discipline: Anatomy, Human Biology
Pedagogical Use: Learn
Audience Level: Middle school 6-8, High school lower division 9-10, High school upper division 11-12

Author and Copyright


Authors and Editors: American Association for the Advancement of Science
Publisher: AAAS
Date Published: 2005-01-01
Date Added to BEN: 2008-05-15
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
American Association for the Advancement of Science



"Omic" Risk Assessment

Integration of data from different techniques is the key to effective validation of “hits” in large-scale screens. A discussion of validation methods for siRNA screens and protein-interaction screens reveals how to go beyond an arbitrary assignment of relevant to a more biologically meaningful identification of targets.

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User Rating: 3 / 5 stars - 5 vote(s).


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Classifications


Resource Type: Journal article/Issue, Photograph
Discipline: Bioinformatics Genomics & Proteomics, Cell biology, Genomics, Proteomics
Pedagogical Use: Learn, Research, Teach
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: Michael B. Major of Lineberger Comprehensive Cancer Center and Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Randall T. Moon of Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine
Publisher: American Association for the Advancement of Science
Date Published: 2009-05-26
Date Added to BEN: 2013-05-11
Format: application/pdf, text/html
Copyright and other restrictions: Yes
Cost: No
Cost Description: Copyright © 2009 by the American Association for the Advancement of Science and the Board of Trustees of the Leland Stanford Junior University

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Collection:
STKE/Science Signaling



"Sleuron Virus" (Human Learning - Kinetic City)

The "Sleuron virus module" focuses on learning, practicing, and the ability to get better at things. Among the concepts covered are motor skills (such as reaction time), the human brain, short term memory, and the ability to give and receive accurate instructions. This learning object may be used as reinforcement of learning objectives accomplished in the classroom. The Sleuron Virus module is equipped with a computer-based simulation mind game, creative writing exercise for independent study, and art-centered exercises, as well as lesson plans hands on games and activities designed for a group. KINETIC CITY DESCRIPTION: "Kinetic City"(www.kineticcity.com) is a fun, Web-based after-school science club for kids, ages 8 through 11. It combines exciting online animations and activities with boxes of hands-on science experiments. Children earn "Kinetic City" power points and collect stickers as they complete missions and learn standards-based science content. Here's how it works: The "Kinetic City" super crew (Keisha, Curtis, Megan and Max) needs the help of Earth kids to save their planet Vearth, from the science-distorting computer virus Deep Delete. Each of Deep Delete's 60 hideous strains attacks a different area of science with disastrous consequences. After each attack, teams of Earth kids fight back by viewing a short online animation describing the situation on Vearth; performing a series of activities to re-learn the lost science and going on a mission to Vearth during which they answer science questions and gobble up Deep Delete viruses. Their scores appear on their own Kinetic City Club Web page. "Kinetic City" is produced by the American Association for the Advancement of Science (AAAS), with a grant from the National Science Foundation. AAAS writes the "Project 2061 Benchmarks for Science Literacy," which forms the basis of most state science standards.

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User Rating: 3.1 / 5 stars - 16 vote(s).


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Classifications


Resource Type: Animation, Audio, Simulation, Assignment/Activity (non-laboratory)
Discipline: Neurobiology, Psychology
Pedagogical Use: Learn, Teach
Audience Level: Middle school 6-8, High school lower division 9-10, High school upper division 11-12

Author and Copyright


Authors and Editors: American Association for the Advancement of Science
Publisher: AAAS
Date Published: 2005-01-01
Date Added to BEN: 2008-03-20
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
American Association for the Advancement of Science



More search results: 1 2 3 4 5 6 ... 734

     
   

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