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Displaying results for the 5 latest resources added by GSA.



Revised College Genetics Laboratory Exercise for Witnessing Phenotypic and Molecular Evolution in the Fruit Fly

This is an update to a published laboratory that allows students to observe both phenotypic and molecular evolution through natural selection in a population of fruit flies (Drosophila simulans). The activity takes advantage of eye color variation and molecular variation in a live model organism to demonstrate concepts of transmission genetics and evolutionary genetics. To make this exercise more accessible to a broader audience of novice fly handlers, the authors constructed strains of Drosophila melanogaster that eliminate the difficult, time-consuming steps of collecting virgin females to be used in crosses, and designed new markers to be used with this species. This revision describes the changes to the activity, how the strains were constructed, and results from a test-run of the revised activity. This activity utilizes the protocol and concepts originally published in Evolution: Education and Outreach in 2012 by Caiti Heil, Mika Hunter, Juliet Noor, Kathleen Miglia, Brenda Manzano-Winkler, Shannon McDermott, and Mohamed Noor; any of the original materials are included here with permission, and can also be accessed at the Noor Lab website.

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Classifications


Resource Type: Laboratory or Hands-On Activity
Discipline: Evolutionary Biology, Genetics & Heredity, Molecular Biology
Pedagogical Use: learn
Audience Level: Undergraduate upper division (Grades 15-16)

Author and Copyright


Authors and Editors: Jennifer N Gredler of Duke University, Dr. Mohamed AF Noor of Duke University, Brenda Manzano-Winkler of Duke University
Publisher: Genetics Society of America
Date Published: 2015-07-22
Date Added to BEN: 2015-08-26
Format: text/html
Copyright and other restrictions: No
Cost: No

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Collection:
Genetics Society of America



Demonstrating Meiosis Using Manipulatable Chromosomes and Cells

This resource is an in-class, hands-on, manipulative modeling exercise designed to allow students to visualize and demonstrate meiosis in a diploid cell by manipulating a simplified three-dimensional model of chromosomes in a model germ cell; this is for students to complete individually but work through in small groups. Meiosis is consistently a challenging process for students to grasp, likely because it occurs on a microscopic and molecular level that is abstract to student thinking. By allowing each student to manipulate individual model chromosomes in a model cell, the activity makes meiosis a tangible and accessible concept to students in a way that allows students to make sense of the abstract properties of meiosis. It can specifically incorporate challenging aspects of meiosis and processes that occur during or as a result of meiosis that are often difficult for students to understand or visualize, including: crossing over; ploidy of the cells in different stages of meiosis; the number of chromosomes, chromatids, and DNA molecules at different stages of meiosis; how individual maternal and paternal alleles travel to individual gametes; how meiosis leads to genetic variation; and how mistakes in meiosis can result in aneuploidy. The implementation of this activity is designed to appeal to visual, auditory, and kinesthetic learning styles.

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Classifications


Resource Type: Laboratory or Hands-On Activity, Lecture / Lecture Outline / Lecture Notes
Discipline: Cell biology, Genetics & Heredity, Molecular Biology
Pedagogical Use: learn
Audience Level: High School upper division (Grades 11-12), Undergraduate lower division (Grades 13-14), Undergraduate upper division (Grades 15-16)

Author and Copyright


Authors and Editors: Mary F. Durham of University of Nebraska-Lincoln
Publisher: Genetics Society of America
Date Published: 2015-05-15
Date Added to BEN: 2015-08-26
Format: text/html
Copyright and other restrictions: No
Cost: No

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Collection:
Genetics Society of America



Exploring Genetic Variation in a Caffeine Metabolism Gene

This laboratory unit illustrates the core concept of genetic variation by having students analyze a single nucleotide polymorphism (SNP) from their own DNA. Briefly, DNA is isolated from cheek cells, and a specific region of the CYP1A2 intron is amplified via PCR. Restriction fragment length polymorphism (RFLP) analysis is then used to detect the SNP,which is visualized with gel elecrophoresis. Students can generate a hypothesis based on their own behavior, test it, and interpret the results. Overall, this series of laboratories exposes students to a variety of basic molecular biology techniques, correlates to an observable phenotype without causing serious health concerns, and caters to studentsÂ’ innate desire for self-discovery.

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Classifications


Resource Type: Laboratory or Hands-On Activity
Discipline: Genetics & Heredity, Molecular Biology
Pedagogical Use: learn
Audience Level: Undergraduate lower division (Grades 13-14), Undergraduate upper division (Grades 15-16)

Author and Copyright


Authors and Editors: Yvelande Zephyr of Rollins College, Dr. Susan Walsh of Rollins College
Publisher: Genetics Society of America
Date Published: 2015-03-09
Date Added to BEN: 2015-08-26
Format: text/html
Copyright and other restrictions: No
Cost: No

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Collection:
Genetics Society of America



DNA Replication: A Case Discussion of a Landmark Paper by Meselson and Stahl

This exercise couples a classic primary literature paper detailing the process of DNA replication with a set of questions designed to both guide students through the process of reading papers and delve deeply into the critical concept of replication. Meselson and Stahl (1958) is an ideal paper to introduce students to the art of reading papers and appreciating beautiful science; not only was this a landmark experiment for the essential process it helped to define, but it was also recognized for its elegant simplicity.

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Classifications


Resource Type: Assignment/Activity (Non-Laboratory/Non-Hands on Activity), Lesson Plan
Discipline: Genetics & Heredity, Molecular Biology, Genomics
Pedagogical Use: learn, teach
Audience Level: Undergraduate upper division (Grades 15-16), Graduate

Author and Copyright


Authors and Editors: Shoumita Dasgupta of Boston University School of Medicine Biomedical genetics
Publisher: Genetics Society of America
Date Published: 2013-12-30
Date Added to BEN: 2015-08-26
Format: text/html
Copyright and other restrictions: No
Cost: No

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Collection:
Genetics Society of America



Cystic Fibrosis: Exploration of Evolutionary Explanations for the High Frequency of a Common Genetic Disorder

The authors present a guided classroom exercise in which students derive and evaluate hypotheses to explain the relatively high incidence of cystic fibrosis (and the alleles responsible) in European and European-derived human populations. Through this exercise students develop their abilities to apply evolutionary concepts, and generate and evaluate evolutionary hypotheses. Students also develop understanding of human genetic variation and the population genetics of genetic disorders.

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Classifications


Resource Type: Digital Presentation (Powerpoint), Assignment/Activity (Non-Laboratory/Non-Hands on Activity)
Discipline: Evolutionary Biology, Genetics & Heredity, Human Biology, Molecular Biology, Population Biology, Public Health
Pedagogical Use: learn, teach
Audience Level: Undergraduate lower division (Grades 13-14)

Author and Copyright


Authors and Editors: Daniel Taub of Southwestern University, Joshua Page of Southwestern University
Publisher: Genetics Society of America
Date Published: 2013-10-16
Date Added to BEN: 2015-08-26
Format: text/html
Copyright and other restrictions: No
Cost: No

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Collection:
Genetics Society of America



     
   

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